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KMID : 0984920140160010047
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Journal of Skin Barrier Research
2014 Volume.16 No. 1 p.47 ~ p.55
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Moisturizing Ingredients and Their Safety
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Jeong Se-Kyoo
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Abstract
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Currently, use of moisturizers is considered as being prerequisite for both cosmetic andtherapeutic purposes, because dry skin, or xerosis, is important not only as a cosmetic problem, but also clinically important factor for triggering or aggravating disease symptoms. Use of appropriate moisturizer can improve the cosmetic appearance of the skin but, more importantly, sufficient moisturization of skin is a basic treatment regimen for many skin diseases. Enormous kinds of pharmaceutical and cosmetic ingredients have been used for making moisturizers andcurrent knowledge about the mechanisms by which the agents work continues to evolve along with our understanding of skin structure and function, especially about the stratum barrier function. Classical moisturizers are usually made by the combination of emollients, occlusive agents and humectants, mostly combined by emulsifiers. Recent advances in skin barrier research further identifies new class of moisturizing ingredient: ceramide and physiologic lipid mixture. Fragrances and other aesthetic properties-improving ingredients are also used for moisturizers. In this review, commonly used moisturizing ingredients and their working mechanisms are briefly discussed. Also, development of new moisturizing ingredients based on epidermal permeability barrier function will be also explained. Lastly, potential side effects of commonly used cosmetic ingredients will be also discussed.
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KEYWORD
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Ceramide, Emollient, Humectant, Moisturizer, Safety assessment, Skin barrier function
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